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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on practical aspects of the study design, such as the recruitment process and consent in adherence, as well as the use of standard equipment.

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Pragmatic Software, a software firm provides a variety of casino games to online gambling platforms. Its iGaming software is used by the top operators and land based casinos. The company provides front-end site design tools, analysis and marketing, promotions security payment systems, customer support, and bug reporting. Additionally, the company offers its players a secure environment that features high-quality graphics and gameplay.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and had participants from different geographic areas. This kind of heterogeneity, which is vital for a pragmatic trial to be reliable and to reduce bias in the results is also essential. A high degree of heterogeneity, however could cause issues with the design of the trial.

Pragmatic Play is one of the major players in the live casino market, offers an array of traditional table games, including Blackjack and Roulette. The live studios of the company in Romania and Malta offer customers an authentic experience in gambling as well a full variety of betting options via virtual. The company also offers a variety of game shows which make online gambling exciting and interactive. Some of these shows have live hosts, while others are hosted by famous personalities from the industry.

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Pragmatic Play offers not only mobile-friendly slot machines but also live casino and table games. Pragmatic Play is licensed and regulated by a variety of regulatory bodies which include the Malta Gaming Authority and UK Gambling Commission. The games offered by the company are secured with high-end encryption and its security team is on hand to assist players in any situation.

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Legality

Pragmatic Play has gained a reputation for offering top-quality games and an outstanding user experience. Its software can be used on mobile devices as well as in various languages. It has earned itself the status of one of the most popular casino gaming platforms despite its relatively young age. Wolves is one of the most recent releases which is a five-reel slot machine with a hefty RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. Usually, they are ordered by policymakers and practitioners to help guide their decisions. They are also a good method of determining the causality between an intervention and its results. They should, however, not be used to replace explanatory studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the features of a practical trial, including the recruitment process, the design and implementation of the intervention, and monitoring.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to remember that the majority were conducted in primary-care settings.